One catalyst at a time. Some of the magic happens before, some at the time of, some after. There's no way to tell which or in what combination. The market doesn't care when you need it to move — follow along and see how it unfolds.

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Portfolio catalyst calendar

Verified events — May 2026 through 1H 2027

Done Date Position Catalyst Impact
May 28, 2026 MDNAF Offering closes ($0.50/unit, units include warrants at $0.65) Dilution magnitude locked in
End H1 2026 (now) TSHA REVEAL Part A 12-month follow-up data (all 12 patients) Durability of 100% response
June 2026 VLTLF First ton commercial sale execution at Select Texas site Validates commercial revenue inflection
Q2 2026 TSHA REVEAL Pivotal dosing completion Starts 6-month follow-up clock
Q2 2026 TSHA ASPIRE dosing completion (3 patients age 2 to <4) Supports broad label ≥2 years
Q2 2026 VSTM RAMP 205 expansion cohort update (1L PDAC) PDAC thesis validation
Late Q2 2026 (June) DFTX EMERGE Phase 3 topline (DT120 ODT in MDD) Biggest near-term binary
Mid-2026 DFTX Ascend Phase 3 initiation (second MDD trial) Expands MDD program
Anytime 1H 2026 VSTM VS-7375 TARGET-D 101 expansion cohort data KRAS G12D validation
Early Q3 2026 DFTX Voyage Phase 3 topline (DT120 ODT in GAD, 214 pts) Second DFTX Phase 3
Q3 2026 IMMX NEXICART-2 topline (40-pt BLA-enabling, AL amyloidosis) BLA-enabling, first FDA tx
Q3 2026 TENX LEVEL Phase 3 topline (230-pt PH-HFpEF, TNX-103) $50 target trigger
Late Q3 2026 DFTX Panorama Phase 3 topline (DT120 ODT in GAD, 200 pts) Third DFTX Phase 3
Q3 2026 DFTX DT402 ASD Phase 2a initial data Pipeline expansion validation
2H 2026 MDNAF MDNA11 expanded clinical data (IL-2 Superkine) IL-2 thesis validation, M&A trigger
2H 2026 KYTX Phase 2 gMG longer-term follow-up data (1-year+) Supports gMG Phase 3 thesis
2H 2026 IMMX BLA submission for NXC-201 (after topline) Approval countdown begins
2H 2026 CNVIF US commercial launch (HiLight intravascular imaging) Revenue ramp + M&A visibility
2H 2026 LUCD Medicare LCD decision (timing TBD) 2-3x stock catalyst per thesis
Late 2026 VLTLF Strategic JV updates and formal NASDAQ uplisting targets Uplisting visibility and institutional access
Sept 30, 2026 GLSI Insider lock-up expiration (leak-out plan begins) Share dynamics shift
Q4 2026 KYTX SPS BLA rolling submission completion Priority Review countdown
Q4 2026 TSHA PPQ manufacturing campaign completion BLA-enabling milestone
Q4 2026 / Q1 2027 TSHA REVEAL 6-month Pivotal interim (BLA-supporting) Big TSHA binary
Q4 2026 / Q1 2027 GLSI 14-event interim analysis (FLAMINGO-01) Biggest portfolio catalyst
Q1 2027 TSHA BLA submission (post 6-month interim) FDA review begins
Q1 2027 DFTX NDA submission for DT120 ODT (assuming positive Phase 3s) Commercial pathway opens
Q1 / Q2 2027 KYTX Potential SPS approval (Priority Review timeline) Commercial revenue begins
Q1 / Q2 2027 IMMX FDA action / Priority Review on NXC-201 BLA Pre-approval re-rate
1H 2027 VSTM VS-7375 registrational Phase 2 initiation (PDAC, NSCLC, CRC) Locks registrational path
Mid-2027 VSTM RAMP 301 Phase 3 topline (recurrent LGSOC) Major VSTM binary
Ongoing HROW Quarterly commercial revenue + M&A optionality Tripling thesis progression
Ongoing VSTM AVMAPKI FAKZYNJA commercial sales (LGSOC) 50%+ QoQ growth confirmed
Ongoing GLSI Event accumulation updates (toward 14 events) Triggers interim analysis
Highlighted rows = top portfolio-impact catalysts Compiled May 18, 2026 — verified against company SEC filings